Composite particles, methods, and in vivo diagnostic system

» Número: US9861710B1 (B1)

» Fecha Publicación: 09/01/2018

» Solicitante: VERILY LIFE SCIENCES LLC?[US]

» Inventor: RUCKH TIMOTHY TORDELLA?[US]; KAM KIMBERLY?[US] (3)

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A system is provided which includes the composite nanoparticles configured to bind with a target analyte, the composite nanoparticles including a polymer matrix; nanoparticles at least one type; reporter labels at least one type; and targeting entities at least one type, wherein the nanoparticles at least one type, the reporter labels at least one type and the targeting entities at least one type are encapsulated in the polymer matrix; a body-mountable device mounted on an external surface of a living body and configured to detect a target analyte binding response signal transmitted through the external surface, wherein the target analyte binding response signal is related to binding of the composite nanoparticles with one or more target analytes; and a processor configured to non-invasively detect the one or more target analytes based on the target analyte response signal. Composite nanoparticles and methods for use and for making are also provided.

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